A recent study has identified a significant correlation between AMY1 gene copy number and salivary amylase activity in individuals with T2D or prediabetes, revealing that higher AMY1 copy numbers correspond to increased enzyme activity. Conducted in Ithaca, New York, the study analyzed saliva and genetic data from 196 adults. Results demonstrate that each additional AMY1 copy leads to a 43% rise in salivary amylase activity among diabetic participants, suggesting a potential compensatory mechanism for glucose regulation. The study highlights the need for further prospective research to explore the implications of salivary amylase monitoring in early diabetes detection.