A decade-long follow-up of the Swiss Multicenter Bypass or Sleeve Study found that Roux-en-Y gastric bypass resulted in greater excess body mass index loss than laparoscopic sleeve gastrectomy, with patients experiencing higher conversion rates due to gastroesophageal reflux disease and insufficient weight loss.

The trial enrolled 217 patients with severe obesity between 2007 and 2011 across 4 bariatric centers. Patients were randomized to undergo sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB), with weight loss and metabolic outcomes assessed over 10 years. Follow-up data were available for 65.4% of participants. Both procedures resulted in substantial improvements in obesity-related comorbidities, including type 2 diabetes (T2D), dyslipidemia, and hypertension. Results align with the SLEEVEPASS trial, which also reported better weight loss outcomes with RYGB. It should be noted that patients with severe GERD were excluded from the study, which might impact the generalizability of findings.

Source: JAMA Surgery