1. Abdominal subcutaneous fat increased risks of endometrial, liver, and esophageal adenocarcinoma.
2. Gluteofemoral fat lowered risks of breast cancer and meningioma.
Visceral and liver fat raised risk of liver cancer.
3. Pancreas fat increased risk of endometrioid ovarian cancer.
4. Abdominal subcutaneous fat reduced risks for luminal B/HER2-negative-like and triple-negative breast cancer.
5. Mediators included insulin, sex hormone–binding globulin, IGFBP-1, and adiponectin.
6. The study used Mendelian randomization with data from more than 700,000 patients of European ancestry.
7. Limitations: ancestry restriction, missing instruments, and overlapping effects among fat depots.
