A study indicates that 3,3'-diindolylmethane (DIM), a supplement from cruciferous vegetables, notably alters urinary estrogen metabolite levels in postmenopausal women undergoing transdermal estradiol therapy. In a cohort of 1,458 women, 108 used DIM, displaying significant variations in estrogen profiles, with lower estrone and estriol but higher 2-hydroxyestrone and 2-hydroxyestradiol levels. The findings suggest that DIM may modify hormonal therapy's pharmacokinetics via cytochrome P450 enzyme induction, raising questions about clinical implications and the need for healthcare providers to inquire about supplement use.

Source: Menopause