- Prediabetes participants with higher abundance of gut microbiota gene BT2160 experienced greater reduction in fasting blood glucose with broccoli sprout extract (BSE).
- The mean fasting glucose reduction with BSE was 0.2 mmol/L compared with placebo.
- BSE group reported adverse effects, primarily gastrointestinal symptoms, more frequently.
- Exploratory analyses identified a subgroup of participants with mild obesity, low insulin resistance, and reduced insulin secretion who exhibited a 0.4 mmol/L reduction in fasting glucose.
- Participants with higher baseline BT2160 abundance demonstrated greater sulforaphane serum concentrations and improved glycemic response.
Broccoli Sprout Extract in Prediabetes: Microbiota and Glycemic Variability
Conexiant
February 17, 2025
