Psoriasis–AD Switching May Mimic Treatment Failure
Recognizing sustained switches between the two diseases can prevent premature discontinuation of effective biologics and point toward Janus kinase inhibitors, a 148-patient cohort suggests.
Edited
Andrea Surnit
Conexiant June 15, 2026
5 Topic Commentaries
Psoriasis–AD Switching May Mimic Treatment Failure
Yi-Ju Chen, MD, PhD
Dermatology
•
Taichung Veterans General Hospital
This cohort study found that patients with AD receiving treatment with dupilumab had an increased psoriasis risk compared with those receiving other systemic agents.
Biologics used for plaque psoriasis have been reported to be associated with an atopic dermatitis (AD) phenotype, or paradoxical eczema, in some patients.
Tumor necrosis factor (TNF) and interleukin (IL)-12/23 (ustekinumab) blockade are highly effective treatments for many autoimmune conditions including psoriasis, but rarely these agents can paradoxically induce psoriasiform eruptions.
Our study describes how advanced molecular profiling can be used to clearly distinguish different inflammatory skin diseases – including the common diseases psoriasis and atopic dermatitis – and also to better diagnose rarer and much more difficult cases.
Bio:Andrea Surnit is an editor for Conexiant whose work includes cardiology news and journal coverage. She edited Conexiant reporting on proactive care coordination for older Medicare patients with cardiovascular disease or cardiovascular risk factors.
5 Topic Commentaries
Psoriasis–AD Switching May Mimic Treatment Failure
Yi-Ju Chen, MD, PhD
Dermatology
•Taichung Veterans General Hospital
Ali Al‑Janabi, MA (Cantab)
Dermatology
•The University of Manchester
Michael J. Sladden, MAE, FACD, MRCP
Dermatology
•University of Tasmania
Francis Yi Xing Lai, MBBS (Hons)
Dermatology
•St John’s Institute of Dermatology, King’s College London/Guy’s and St Thomas’ NHS Foundation Trust
Jeffrey B. Cheng, MD, PhD
Dermatology
•University of California, San Francisco
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