5 Key Takeaways

• 1

  Benzene levels in benzoyl peroxide products range from 0.19 to 35.3 parts per million, influenced by formulation factors.

• 2

  Leave-on formulations have lower benzene concentrations compared to wash-off products, with a significant coefficient of -5.83.

• 3

  Products with excipients indicative of hot processing showed higher benzene concentrations, with a coefficient of 7.34.

• 4

  The presence of antioxidants like butylated hydroxytoluene (BHT) was associated with lower benzene concentrations.

• 5

  Formulation characteristics may influence benzene formation more than degradation over time at room temperature.