In a large cohort study of 180,483 acetaminophen users aged 65 or older, researchers found that use was associated with a 36% increased risk of lower gastrointestinal bleeding.
A recent multicenter trial investigated the impact of potassium nitrate supplementation on exercise capacity and quality of life in patients with heart failure with preserved ejection fraction, revealing interesting insights into blood nitric oxide metabolites.
A study evaluating systematic reviews used to develop dietary guidelines for Americans revealed 'critically low' quality and significant methodological weaknesses, raising concerns about reliability and reproducibility.
New atrial fibrillation management guidelines embrace a novel 4-stage classification system and early rhythm control strategy, with clinical trials showing a 21% reduction in cardiovascular outcomes when rhythm control is initiated within 12 months of diagnosis.
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New guidelines for congenital heart disease screening recommend a single retest and require ≥95% oxygen saturation in both pre- and post-ductal measurements, aiming to simplify detection while maintaining accuracy.
Study finds both low and high breakfast energy intake are linked to worse cardiometabolic outcomes in older adults, with high energy intake associated with a striking 28.1 mg/dL increase in triglycerides compared to optimal 20-30% daily caloric intake.
A recent study shows that even 3.4 minutes of vigorous intermittent lifestyle physical activity per day could significantly reduce cardiovascular risk, particularly in non-exercising women.
In a 17,642-patient cohort study validating ISAR-REACT5's findings, prasugrel showed particular benefit in STEMI patients, with a striking 38% relative risk reduction in adverse events compared to ticagrelor, while maintaining similar bleeding risks.