1. Syphilis linked to higher risk of myocardial infarction, stroke, peripheral artery disease, and aortic disease.
2. Risk strongest in late-stage (tertiary) syphilis.
3. No association with heart failure, atrial fibrillation, aortic regurgitation, or venous thromboembolism.
4. Suggests independent infection-related cardiovascular risk.
5. Supports adding cardiovascular risk assessment to syphilis care.

Source: JAMA Network Open