1. The absence of five major cardiovascular risk factors at age 50 may lead to over a decade of additional life expectancy.
2. Midlife modification of hypertension and smoking yielded the greatest gains in overall survival and cardiovascular health.
3. The study involved over 2 million participants across 39 countries and six continents.
4. Geographical variations in lifetime risk and the impact of specific risk factors were observed.
5. The study findings emphasized the importance of primary prevention strategies targeting modifiable risk factors.

Source: The New England Journal of Medicine