In this secondary analysis of the SENIOR-RITA randomized clinical trial including 469 frail older patients with non–ST-elevation myocardial infarction, an invasive strategy did not reduce cardiovascular death or nonfatal myocardial infarction compared with conservative management over a median 4.1 years. Increasing frailty was associated with a potential signal for harm with invasive treatment, highlighting the need for frailty-informed decision-making.

Source: JAMA Network Open