- High prevalence of amyloid in CTS surgery patients: Tenosynovial amyloid deposition was found in 56% of older patients undergoing surgery for idiopathic carpal tunnel syndrome.
- Moderate yield for cardiomyopathy: Among patients with amyloid-positive biopsies who completed evaluation, 17% were diagnosed with ATTR-CM (approximately 1 in 6).
- Disease detected at an early stage: Most screening-detected patients had mild disease (89% NAC stage I) and were asymptomatic (78% NYHA class I).
- Biomarkers may be normal in early disease: A substantial proportion of patients with ATTR-CM had normal NT-proBNP (22%) and troponin I (89%) levels at diagnosis, suggesting biomarker-based screening alone may miss early cases.
- Screening may broaden phenotype recognition: Screening identified a higher proportion of women compared with clinically diagnosed cohorts (22% vs 4%), suggesting potential underrecognition of ATTR-CM in women in routine practice.
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