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TAVR and surgery had similar 7-year composite outcomes (34.6% vs 37.2%).
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Mortality, stroke, and rehospitalization rates were nearly identical between groups.
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Valve durability matched: failure occurred in 6.9% (TAVR) vs 7.3% (surgery).
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TAVR markedly reduced new-onset atrial fibrillation (17.7% vs 43.5%).
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Higher risks after TAVR included LBBB, valve thrombosis, pacemaker implantation, and paravalvular regurgitation.
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About 73% of both groups were alive without valve failure at 7 years.
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Trial generalizability was limited; Edwards Lifesciences funded and contributed to study design and analysis.
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