- Genotype-guided prescribing increased phenotype-concordant opioid selection.
- CYP2D6-guided therapy did not improve postoperative pain scores.
- Overall opioid use was similar between groups.
- Multimodal analgesia was common across both study arms.
- Routine CYP2D6-guided opioid prescribing showed no clinical benefit.
Source: JAMA Network Open
