July 25, 2025

Tofacitinib Curbs Inflammation, Not Thrombosis Risk

Tofacitinib dampens inflammatory cytokine production in rheumatoid arthritis models but fails to counteract endothelial prothrombotic responses, highlighting ongoing cardiovascular safety concerns.

Conexiant

July 15, 2025

Genetic Markers Don’t Guide RA Drug Choice

A large UK study found no significant difference in treatment effectiveness between abatacept and adalimumab for rheumatoid arthritis, regardless of patients’ HLA-DRB1 genetic profiles.

Conexiant

July 15, 2025

Methotrexate Shows No Knee OA Symptom Benefit, Study Finds

A 52-week randomized clinical trial found no significant difference between methotrexate and placebo in reducing pain or effusion-synovitis in patients with inflammatory knee osteoarthritis.

Conexiant

July 14, 2025

Skin Autoimmune Disorders Tied to Longer Cancer Survival

A large nationwide study in Taiwan found that patients with autoimmune skin diseases had lower all-cause and cancer-specific mortality following cancer treatment compared with those without these conditions.

Conexiant

July 10, 2025

Tramadol Carries Lowest Constipation Risk Among Opioids

The UK hospital study of over 80,000 patients found that certain opioids, including morphine and oxycodone, carried a higher risk of severe constipation compared with others.

Conexiant

July 09, 2025

Recombinant Zoster Vaccine Linked to New-Onset Lupus

Researchers report the first documented case of systemic lupus erythematosus following Shingrix vaccination.

Conexiant

July 09, 2025

Upadacitinib Cuts Flares, Steroids in GCA Trial

A new phase 3 study found that daily oral upadacitinib 15 mg, combined with a shorter 26-week steroid taper, improved sustained remission rates and reduced steroid use in patients with giant-cell arteritis.

Conexiant

July 07, 2025

Sexual Dysfunction Common in Men With r-axSpA: Study

Men with r-axSpA reported lower sexual satisfaction, though no genetic link to ED was found.

Conexiant

July 02, 2025

Metabolic Syndrome Strongly Linked to Oral Diseases

New research highlights strong associations between metabolic syndrome and several oral diseases—including periodontitis, caries, and peri-implantitis—calling for more longitudinal studies to explore causation and improve patient care.

Conexiant