A large UK study found no significant difference in treatment effectiveness between abatacept and adalimumab for rheumatoid arthritis, regardless of patients’ HLA-DRB1 genetic profiles.
A 52-week randomized clinical trial found no significant difference between methotrexate and placebo in reducing pain or effusion-synovitis in patients with inflammatory knee osteoarthritis.
A large nationwide study in Taiwan found that patients with autoimmune skin diseases had lower all-cause and cancer-specific mortality following cancer treatment compared with those without these conditions.
The UK hospital study of over 80,000 patients found that certain opioids, including morphine and oxycodone, carried a higher risk of severe constipation compared with others.
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A new phase 3 study found that daily oral upadacitinib 15 mg, combined with a shorter 26-week steroid taper, improved sustained remission rates and reduced steroid use in patients with giant-cell arteritis.
New research highlights strong associations between metabolic syndrome and several oral diseases—including periodontitis, caries, and peri-implantitis—calling for more longitudinal studies to explore causation and improve patient care.