In a target-trial emulation of more than 600,000 veterans, GLP-1 RA initiators saw fewer new substance use disorders—and patients with existing SUDs had fewer overdoses, hospitalizations, and deaths.
Phase 2a trial found reduced nicotine craving and weight loss with semaglutide, but no significant between-group difference in cigarettes smoked per day.
WhatsApp-based low-carbohydrate nutrition education was linked to short-term glycemic, weight, and medication-use improvements in a small primary care trial
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Patients with chronic lung disease had numerically lower remission rates and substantially more serious adverse events in a 5-year Japanese registry study of late-onset rheumatoid arthritis.