Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.
In a target-trial emulation of more than 600,000 veterans, GLP-1 RA initiators saw fewer new substance use disorders—and patients with existing SUDs had fewer overdoses, hospitalizations, and deaths.
Older patients with documented cognitive impairment also experienced greater postoperative functional decline following elective total knee arthroplasty
A nationwide matched cohort study found higher suicide incidence more than 1 year following rotator cuff repair, though the findings were based on a small number of events