A recent randomized trial evaluated the effects of postdischarge oral ondansetron in 1,030 pediatric patients visiting emergency departments in Canada for vomiting due to acute gastroenteritis. The study revealed that administering ondansetron after discharge significantly lowered the risk of moderate-to-severe gastroenteritis within a week, with only 5.1% developing severe illness compared to 12.5% in the placebo group. Benefits included reduced vomiting frequency and decreased healthcare visits, indicating ondansetron's potential to manage pediatric gastroenteritis effectively.

Source: The New England Journal of Medicine