1. Inhaled isoflurane is as effective as midazolam for sedation in children.
2. Study involved 92 critically ill children on mechanical ventilation.
3. Isoflurane reduced opioid use significantly.
4. Shorter median extubation time was observed with isoflurane.
5. Most adverse events were mild or moderate.
6. Approximately 39% of isoflurane patients needed rescue sedation.
7.  Efficacy assessed using the COMFORT Behavior scale.

Source: The Lancet Respiratory Medicine