Consider GLP-1 RAs as a potential cause of chronic cough: When common etiologies don’t fit a patient’s presentation, clinicians should include GLP-1 receptor agonists in the differential—especially with long-acting formulations.

Reflux-focused evaluation may be warranted: Because GLP-1 RAs can delay gastric emptying, more aggressive assessment and management of laryngopharyngeal or gastroesophageal reflux may improve cough symptoms.

Be alert to atypical GERD presentations: Many patients with reflux lack GI symptoms, meaning chronic cough may be the first clue; this is particularly relevant for OTO and primary care.

Interdisciplinary collaboration may benefit refractory cases: Otolaryngology, endocrinology, and primary care should coordinate when chronic cough persists, including discussing risk-benefit considerations for a potential medication pause.

Monitor patients on long-acting GLP-1 RAs more closely: These formulations showed stronger associations with chronic cough, suggesting a need for heightened clinical awareness in follow-up.