1. Most medications reviewed do not directly impact fracture healing outcomes. 2. Nonsteroidal anti-inflammatory drugs (NSAIDs) may associate with delayed healing. 3. Corticosteroids hinder bone formation. 4. Vitamin K antagonists increase fracture risk. 5. Diabetes is linked to complications in healing. 6. Polypharmacy complicates treatment outcomes. 7. Study limitations include heterogeneity and lack of risk assessments. 8. Consider patient characteristics when evaluating medication impacts.