5 Key Takeaways

• 1

  MIRA-2 and MIRA-3 trials evaluated 0.75% phentolamine ophthalmic solution for reversing pharmacologically induced mydriasis.

• 2

  The trials included 553 healthy participants aged 12 to 80 years, assessing the efficacy and safety of phentolamine.

• 3

  At 60 minutes post-treatment, 37.5% in MIRA-2 and 48% in MIRA-3 achieved near-baseline pupil size with phentolamine.

• 4

  Phentolamine was well tolerated, with mild side effects like conjunctival hyperemia in 11.2% of cases.

• 5

  Researchers suggest further studies on patients with conditions affecting pupillary dynamics to explore functional effects.