5 Key Takeaways

• 1

  A study found an association between semaglutide use and increased long-term risk of nonarteritic anterior ischemic optic neuropathy in diabetes patients.

• 2

  The study analyzed data from over 3 million diabetes patients, matching 174,584 semaglutide users with an equal number of non-GLP-1 RA users.

• 3

  No increased risk of NAION was observed in the semaglutide cohort within the first year; significant risk emerged from year 2 onward.

• 4

  Increased risk of NAION was noted in patients aged 40-64, female patients, and white patients, while older patients showed no significant risk.

• 5

  The study's limitations include reliance on diagnostic codes and inability to establish causality, suggesting the need for future observational studies.