Objective:

To evaluate cervical cancer screening strategies among patients who received human papillomavirus (HPV) vaccination at different ages.

Key Findings:

• Cervical cancer screening intensity can be reduced for HPV-vaccinated women.
• Optimal screening strategies vary by age at vaccination and vaccine type.
• For those vaccinated at ages 12-24, screening every 15-25 years is preferred; for ages 25-30, every 10 years is recommended.
• Reduced screening intensity leads to fewer diagnostic procedures and treatments.

Interpretation:

Screening recommendations should adapt to individual vaccination status to enhance efficiency and reduce unnecessary interventions.

Limitations:

• Requires reliable individual-level vaccination data and organized screening infrastructure.
• Challenges exist in settings like the US where vaccination registries are incomplete.

Conclusion:

Adapting cervical cancer screening strategies based on HPV vaccination status can maintain effective cancer prevention while reducing unnecessary procedures.