5 Key Takeaways

• 1

  The USPSTF has reaffirmed its A recommendation for universal syphilis screening in all pregnant individuals.

• 2

  In 2023, the U.S. reported 3,882 cases of congenital syphilis, the highest in over 30 years, with significant increases over the past decade.

• 3

  Congenital syphilis rates vary significantly by race, with Native American/Alaska Native women having the highest rates at 680.8 cases per 100,000 live births.

• 4

  Screening for syphilis should occur early in pregnancy or at the first available opportunity, using a two-step blood test algorithm for accuracy.

• 5

  The CDC recommends penicillin G as the only effective treatment for syphilis during pregnancy, with desensitization for those with reported allergies.