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Conexiant chevron_right Neurology chevron_right Triple Cardiovascular Therapy Linked With Slower Cognitive Decline
From the Journals

Triple Cardiovascular Therapy Linked With Slower Cognitive Decline

Combination use of antihypertensive, lipid-lowering, and antidiabetic agents shows associations with cognitive preservation and postmortem neuropathologic changes in aging cohorts.

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Full Article Summary Notecard
Research presented at the Alzheimer’s Association International Conference 2025 reveals that older adults using triple therapy for hypertension, high cholesterol, and diabetes experience slower cognitive decline and reduced dementia-related brain changes. The study, involving 4,651 participants, indicates that the use of all three medication classes is linked to improved cognitive functions, particularly in semantic and working memory. Autopsy results showed lower risks of atherosclerosis and Alzheimer pathology in participants on triple therapy, though there is an increased risk of brain infarcts. Dual therapy also showed benefits, while single-class therapy provided some cognitive advantages.

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