A 5-year trial from the INTREPID study demonstrated that bilateral subthalamic nucleus deep brain stimulation (STN-DBS) significantly improves motor function and quality of life in patients with moderate to advanced Parkinson's disease. After one year, motor function improvements reached 51%, gradually declining to 36% by year five. Although serious adverse events were noted, including infections and deaths unrelated to the treatment, patient satisfaction remained high at 94%. The study suggested early intervention with DBS may offer greater benefits.

Source: JAMA Neurology