New research suggests that removing a key immune signaling gene, stimulator of interferon genes (STING), in mice with Alzheimer's disease-related pathology led to reduced amyloid plaque buildup, lower inflammation, improved memory, and cognitive performance. STING-deficient mice displayed behavioral improvements, reduced microglia activation, and improved neuronal health and synaptic function. The findings point to the potential role of STING signaling in Alzheimer's disease pathology and cognitive decline, laying the groundwork for targeted treatments to inhibit STING in the brain.

Source: Alzheimer's & Dementia