- Removing the STING gene in mice with Alzheimer's disease-like pathology reduced amyloid plaque buildup, inflammation, and improved memory.
- STING knockout led to behavioral improvements, reduced microglia activation, and enhanced synaptic health.
- The findings suggest the potential role of STING in Alzheimer's disease pathology and cognitive decline.
- Further studies are needed to investigate the specific cell types affected by STING and develop targeted treatments.
Source: Alzheimer's & Dementia