- Irregular circadian rhythms in adults linked to brain volume loss and dementia risk.
- Disrupted circadian rhythms associated with early brain structural changes and lower cognitive performance.
- Higher CPD associated with 1.11% decrease in hippocampal volume and 1.03% decrease in thalamic volume.
- Participants in highest CPD quartile had 1.37-fold greater risk of developing dementia.
- Sensitivity analyses supported findings consistent across chronotypes.
Source: BMJ Mental Health
