Recent research led by Alexa Romanella from the Philadelphia College of Osteopathic Medicine reveals a potential link between Chlamydia pneumoniae and SARS-CoV-2 infections and the development of Alzheimer's disease through neuroinflammatory pathways. The study consolidates existing literature, highlighting genetic risk factors like the APOEε4 allele and AD biomarkers such as interleukin-6 and CCL2. The findings indicate that both pathogens can penetrate the neuroepithelium and induce chronic neuroinflammation, suggesting significant implications for AD progression, especially in aging populations with genetic predispositions.

Source: Frontiers in Aging Neuroscience