- Omega-3 polyunsaturated fatty acid treatment did not significantly reduce white matter lesion (WML) progression or neuronal integrity breakdown in older adults at risk for dementia.
- Potential benefits were observed for carriers of the apolipoprotein E ε4 allele.
- Omega-3 treatment was safe and well-tolerated.
- No significant differences were observed between groups in medial temporal lobe atrophy or total brain volume change.
- Annual WML accumulation was similar between the omega-3 and placebo groups.
- Significant reduction in neuronal integrity breakdown was observed among APOE*E4 carriers.
- Adverse events and dropout rates were similar between the two groups.
Omega-3 Falls Short in White Matter Battle, but APOE*E4 Carriers May Find a Silver Lining
Conexiant
August 1, 2024
