In this population-based cohort study of 2,157 older adults without dementia, higher total meat consumption was associated with slower cognitive decline and lower dementia risk over 15 years among individuals with APOE ε3/ε4 or ε4/ε4 genotypes, with no significant associations observed in other genotypes. These findings suggest a potential gene–diet interaction in which higher meat intake—particularly unprocessed meat—may mitigate the elevated Alzheimer disease risk associated with APOE4, supporting the need for genotype-specific dietary guidance.

Source: JAMA Network Open