A study involving 4,553 older adults revealed that low levels of vitamin B12, B6, and riboflavin, along with elevated homocysteine, correlate with increased chances of cognitive dysfunction. Notably, individuals carrying the ApoE e4 genotype faced heightened risks when coupled with nutritional deficiencies. An assessment using the Repeatable Battery for Assessment of Neuropsychological Status indicated significant associations between these vitamins, homocysteine levels, and cognitive functionalities. Findings highlight the need for further research on B-vitamin supplementation in at-risk populations.

Source: BMC Medicine