A recent study led by Liviu Aron from Harvard Medical School found a link between reduced lithium levels and Alzheimer's disease (AD) pathology in aged patients. The study revealed that lithium was significantly lower in the prefrontal cortex of patients with mild cognitive impairment and AD compared to other brain regions. In mice on a lithium-deficient diet, researchers observed increased amyloid-beta deposition, phospho-tau accumulation, and behavioral deficits in learning and memory. These findings suggest that lithium replacement could serve as a potential therapeutic strategy for AD.

Source: Nature