1. Reduced lithium levels are linked to Alzheimer's disease pathology.
2. Prefrontal cortex shows significantly lower lithium in Alzheimer's patients.
3. 50% reduction in cortical lithium in mice increased amyloid-beta and phospho-tau.
4. Behavioral deficits in learning and memory were observed in lithium-deficient mice.
5. Potential therapeutic avenue includes lithium replacement with specific salts.

Source: Nature