1. Estradiol accelerates retinal degeneration in female RP mice.
2. Female vision loss begins at 2 months of age.
3. Ovariectomy improves visual function in females.
4. Estradiol reintroduction reverses visual improvements.
5. Mass spectrometry confirmed increased estradiol levels.
6. Elevated expression of Casp4 and Aif1 in RP females.
7. Hormonal effects observed only in diseased mice.
8. Insights into sex-based differences could guide future treatments.

Source: Science Advances