A large prospective analysis from the Human Epilepsy Project 2 found that nearly 70% of patients with focal treatment-resistant epilepsy experienced meaningful seizure reduction over time, independent of baseline seizure frequency, demographics, or prior antiseizure drug failures. Among 126 participants aged 16 to 65 years, repeated-measures modeling showed a mean modeled monthly seizure reduction of almost 69%, with improvements observed across all follow-up durations. Seventeen patients achieved at least three months of seizure freedom, and medication adjustments—made in more than half of participants—were associated with additional seizure reduction despite rarely producing seizure freedom. Neuromodulation approaches, including deep brain stimulation, vagus nerve stimulation, and responsive neurostimulation, did not yield seizure trajectories that differed from those without devices.

Source: JAMA Neurology