1. Nearly 70% of patients with focal treatment-resistant epilepsy experienced substantial seizure reduction over time, regardless of baseline characteristics or prior treatment failures.
2. Mean modeled monthly seizure frequency decreased by almost 69%, with consistent improvement across follow-up durations.
3. A subset of patients achieved prolonged seizure freedom, including four who remained seizure-free for at least 12 months.
4. More than half of participants added an antiseizure medication, which contributed to seizure reduction but rarely resulted in seizure freedom.
5. Neuromodulation therapies—including deep brain stimulation, vagal nerve stimulator, and responsive neurostimulation—did not produce seizure trajectories that differed significantly from those seen in patients without devices.

Source: JAMA Neurology