1. Long-term use of certain NSAIDs has been linked to 12% reduction in dementia risk.
2. Duration, not dosage, emerged as a key factor in protective effects, according to the research.
3. NSAIDs without amyloid-β lowering properties showed a stronger protective association.
4. Protective effects were observed only in participants without the APOE-ε4 allele.
5. However, more research on the association is needed because NSAIDs are currently listed as potentially inappropriate medications for older adults.

Source: Journal of the American Geriatrics Society