A large Swedish cohort study of 6,323 patients found that early-life factors—including infectious mononucleosis, obesity at age 20, and fish intake—were tied to the long-term course of multiple sclerosis (MS). Patients with a history of mononucleosis or obesity were less likely to maintain a benign MS course 15 years after onset, while those who ate fish weekly were more likely to have milder disease. Researchers concluded that infection history and modifiable lifestyle behaviors may influence long-term MS progression, though causality cannot be inferred.
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