- Greater variability in total cholesterol and low-density lipoprotein cholesterol levels over time is associated with increased risk of dementia and cognitive decline in older adults, irrespective of mean cholesterol values.
- The study involved 9,846 participants with a median age of 73.9 years.
- The hazard ratio for dementia comparing the highest versus lowest quartiles of total cholesterol variability was 1.60.
- Cholesterol fluctuations could potentially destabilize atherosclerotic plaques, leading to cerebral blood vessel obstruction.
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