5 Key Takeaways

• 1

  Cytomegalovirus, herpes simplex virus, and Aspergillus species contribute to nonresolving ARDS through immune dysregulation and lung injury.

• 2

  Nonresolving ARDS is characterized by persistent respiratory failure beyond 5 days of mechanical ventilation, leading to high morbidity and mortality.

• 3

  Influenza and COVID-19 are significant risk factors for invasive pulmonary aspergillosis, with mortality rates exceeding 50% in affected patients.

• 4

  Diagnostic challenges exist for viral reactivation and invasive pulmonary aspergillosis, with bronchoalveolar lavage being preferred for accurate detection.

• 5

  Fungal and viral infections may interact in ARDS, complicating treatment and outcomes, though the evidence for causality remains limited.