5 Key Takeaways

• 1

  A single dose of benzathine penicillin G was found noninferior to three doses for early syphilis at 6 months in a randomized clinical trial.

• 2

  Serologic response rates were 76% for the one-dose group and 70% for the three-dose group, with no clinical relapses observed during follow-up.

• 3

  The trial enrolled 249 patients, predominantly men (97%), with 62% identifying as Black and 61% living with HIV.

• 4

  Injection-site pain was reported by 76% of the one-dose group and 85% of the three-dose group, with local tenderness affecting 81% overall.

• 5

  The study faced limitations, including early enrollment cessation due to COVID-19 and discrepancies between overall results and stage-specific analyses.