Superagers aged 80 years and older demonstrate a unique neurobiological profile associated with successful aging: preserved memory and distinct brain anatomy, including thicker cortical regions and lower tau pathology.
Circulating Insulin-like peptide 5 concentrations may reflect colonic exposure to bile acids and help stratify treatment response in patients with chronic diarrhoea, including those with irritable bowel syndrome with diarrhoea and bile acid diarrhoea.
Each additional 1,000 daily steps a day may be associated with a reduction in major adverse cardiovascular events among patients with hypertension, with benefits evident at step counts well below 10,000 steps per day.
Patients with psoriatic arthritis consistently identify nonjoint symptoms such as dactylitis, psoriasis, and uveitis, demonstrating the clinical utility of patient-reported outcome measures.
Estradiol increases susceptibility to retinal degeneration in female mice with retinitis pigmentosa, highlighting hormone-specific effects on neurodegenerative disease pathways.