A recent review analyzed the available academic literature on treatment for delayed ejaculation.
Published in Trends in Urology & Men's Health, researchers included 25 studies from 13 countries across 4 continents covering a range of treatment options, including pharmacological interventions, penile vibratory stimulation, masturbation devices, psychotherapy, cognitive-behavioral therapy, couples therapy, and sex therapy. The studies included a total of 580 patients, with 8 studies describing pharmacological treatments, 1 focusing on penile vibratory technique, 2 on masturbation devices, and the remaining 14 examining various forms of psychotherapy.
A randomized controlled trial investigating the use of a cream containing capsaicin and vanilloid (Camarouf cream) showed promising results. The treatment group, which applied 0.25 ml of the cream per week for 2 months, experienced a statistically significant difference in mean intravaginal ejaculation latency time and quality-of-life questionnaires compared to the placebo group.
Other pharmacological treatments that have shown potential in smaller studies include sildenafil (Viagra), bupropion-SR (150 mg daily for 2 months), pramipexole (0.125–0.5 mg daily), and low-dose combinations of amphetamine and dexamphetamine (Adderall, 5–10 mg approximately 1–2 hours prior to anticipated sexual activity). Non-pharmacological approaches, such as penile vibratory stimulation, which restored orgasm in 72% of participants in one cohort study, and masturbation devices like TENGA, have also demonstrated success in treating delayed ejaculation.
The authors emphasized the importance of a comprehensive assessment when diagnosing and treating delayed ejaculation, including a full medical and sexual history, physical examination, and consideration of partner perspectives and overall sexual satisfaction.
Further research, particularly in the form of well-designed clinical trials, is needed to confirm these findings and develop new therapeutic strategies.
A full disclosure interests can be found in the study.