- 65% of patients with cutaneous graft-vs-host disease reported dry skin, 61% reported tightness, and nearly half struggled with itchiness.
- The study identified five HRQOL domains: skin changes and symptoms, social functioning, psychological and emotional functioning, physical functioning, and general health perceptions.
- Significant gaps in patient-reported outcome measures for cutaneous chronic GVHD were identified, emphasizing the need for disease-specific tools.
- Disease duration varied significantly between the epidermal and sclerotic subtypes.
- The study cohort included 31 adults with active cutaneous chronic GVHD from the University of Pennsylvania.
- Most participants had severe disease, with sclerotic and combination subtypes more frequently classified as severe compared with epidermal cases.
- Thematic analysis revealed prevalent social impairments, psychological effects, and physical limitations.
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