A recent study from researchers at NYU Dentistry has uncovered a connection between periodontal inflammation and shifts in gut bacteria, raising concerns about the broader implications for systemic health.

In the study, published in the journal Microorganisms, researchers highlighted the role of oral health in influencing gut disorders

The study suggested that inflammation in the gums can lead to changes in the gut microbiome, even in individuals who do not have any known gut issues.

“In our study, we hypothesized that periodontal inflammation and its associated subgingival dysbiosis contribute to gut dysbiosis, even in [patients] free of known gut disorders,” emphasized lead study author Angela Kamer, DMD, MS, PhD, Professor in the Ashman Department of Periodontology & Implant Dentistry.

To explore this hypothesis, the researchers assessed the periodontal health and gut microbiomes of 36 elderly participants with no history of gut conditions. They measured periodontal inflammation using clinical assessments and analyzed the microbial composition through advanced sequencing techniques.

The findings revealed a stark difference in bacterial species between individuals with high and low levels of periodontal inflammation. Notably, increased gum inflammation was linked to signs of dysbiosis—an imbalance in gut bacteria.

“These changes were specifically related to reduced activity in healthy gut bacteria and suggest that periodontal inflammation and subgingival microbiota contribute to gut bacterial changes with possible consequences to other systemic diseases,” Dr. Kamer added.

The study underscored the intricate relationship between oral health and overall well-being.

Co-authors from NYU Dentistry included Smruti Pushalkar, Babak Hamidi, Malvin Janal, Vera Tang, Leena Palomo, and Deepak Saxena. As research continues to evolve, it highlights the importance of maintaining good oral hygiene not just for dental health, but also for potentially protecting gut health and preventing systemic diseases.