A universal adhesive with mesoporous bioactive glass outperformed a traditional desensitizing agent, providing immediate and sustained relief from dentin hypersensitivity in a randomized clinical trial.
The split-mouth, blinded study, published in Scientific Reports, evaluated the desensitizing efficacy of a universal dentin adhesive containing mesoporous bioactive glass (MBG) compared to an oxalate/resin polymer agent for dentin hypersensitivity (DH). The trial included 39 participants with sensitive teeth treated with either Hi-Bond Universal (Group HB) containing MBG or MS Coat ONE (Group MS). Sensitivity was assessed using the Schiff Sensitivity Score and Visual Analog Scale (VAS) at baseline, post-application, and at 1- and 2-week follow-ups, using air, cold, and acid stimuli.
Results demonstrated immediate DH reduction to air stimuli in Group HB compared to Group MS (p = 0.017). For cold stimuli, Group HB showed a greater reduction in sensitivity over the follow-up period (p ≤ 0.037), while both groups effectively managed acid stimuli with no significant differences (p > 0.05). VAS scores indicated a gradual reduction in DH across all assessments (p < 0.0001).
Both agents blocked dentinal tubules through different mechanisms: MS Coat ONE formed calcium oxalate crystals, while MBG in Hi-Bond Universal promoted the formation of hydroxycarbonate apatite. MBG demonstrated superior and sustained tubule occlusion, even after brushing abrasion, due to its porous structure and rapid ion release.
“These results suggest distinct response patterns to the interventions, offering valuable insights into the chronological dynamics of DH relief and its subjective perception,” noted researchers.
The study was supported by MEDICLUS Co., LTD