Researchers found that N-acyl homoserine lactone quorum sensing in an in vitro supragingival dental plaque community was oxygen dependent and influenced biofilm composition and function. N-acyl homoserine lactone activity was detected under 5% carbon dioxide but not under anaerobic conditions, and treatment with lactonases reduced biofilm biomass, altered microbial community composition, and changed metabolic output. 

Source: npj: biofilms and microbiomes